Interview with the Innovators

Supported by BridgeBio

Utility of Functional Assessments in the Prognosis of Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
Amy Brownell, MSN, FNP-C, AACC, System Director of Heart Failure, AMITA Health, Chicago, IL; Sarah C. Paciulli, MS, RN, CHFN, NP-C, VCU Health, Richmond, VA; and Lori Roth, MS, PA-C, Advanced Heart Failure Clinic, UT Southwestern Medical Center, Dallas TX, explain the usefulness of the six-minute walk test in clinical practice and to patients.

Addressing Transthyretin Amyloid Cardiomyopathy (ATTR-CM) Through Preservation of Transthyretin
Lori Roth, MS, PA-C, Advanced Heart Failure Clinic, UT Southwestern Medical Center, Dallas, TX; Sarah C. Paciulli, MS, RN, CHFN, NP-C, VCU Health, Richmond, VA; and Amy Brownell, MSN, FNP-C, AACC, System Director of Heart Failure, AMITA Health, Chicago, IL, review the rationale for stabilization as the optimal approach to addressing transthyretin amyloid cardiomyopathy.

The Journey to Diagnosing Transthyretin Amyloid Cardiomyopathy (ATTR-CM) Doesn’t Have to Be a Long One
Lori Roth, MS, PA-C, Advanced Heart Failure Clinic, UT Southwestern Medical Center, Dallas, TX; Sarah C. Paciulli, MS, RN, CHFN, NP-C, VCU Health, Richmond, VA; and Amy Brownell, MSN, FNP-C, AACC, System Director of Heart Failure, AMITA Health, Chicago, IL, discuss the debilitating disease burden and the pathway to transthyretin amyloid cardiomyopathy diagnosis.

Transthyretin (TTR) Protein in Humans: Stabilization vs Destabilization
In this first video clip, Sarah C. Paciulli, MS, RN, CHFN, NP-C, VCU Health, Richmond, VA; Amy Brownell, MSN, FNP-C, AACC, System Director of Heart Failure, AMITA Health, Chicago, IL; and Lori Roth, MS, PA-C, Advanced Heart Failure Clinic, UT Southwestern Medical Center, Dallas, TX, describe the functions of transthyretin (TTR) in its naturally occurring tetrameric form and resulting damage from TTR destabilization.

Serum Transthyretin in the Management of TTR Amyloidosis
Justin L. Grodin, MD, MPH, Assistant Professor of Medicine, UT Southwestern Medical Center, Dallas, TX, explains the current and potentially future utilities of serum transthyretin (sTTR) as a biomarker in the management of transthyretin amyloidosis.

Setting Realistic Treatment Goals and Expectations for Patients with Transthyretin Amyloidosis
Ola Akinboboye, MD, MPH, MBA, Clinical Professor, Cardiology, Donald and Barbara Zucker School of Medicine at Hofstra University/Northwell Health and Medical Director, Laurelton Heart Specialists PC (Rosedale, NY) and Clement C. Eiswirth, Jr., MD, FACC, Medical Director, Cardiomyopathy and Heart Failure Program, Ochsner Health, New Orleans, LA, highlight the importance of early diagnosis and realistic expectations for patients being treated for transthyretin amyloidosis.

Recognizing Clinical Clues of ATTR-CM
Clement C. Eiswirth, Jr., MD, FACC, Medical Director, Cardiomyopathy and Heart Failure Program, Ochsner Health, New Orleans, LA, examines clinical hints for consideration in the diagnosis of ATTR-CM.

Evoking Suspicion of ATTR-CM: Warning Signs
Clement C. Eiswirth, Jr., MD, FACC, Medical Director, Cardiomyopathy and Heart Failure Program, Ochsner Health, New Orleans, LA, offers warning signs of ATTR-CM to consider for patients with heart failure.

Complexities of Transthyretin Amyloid Disposition
Joel N. Buxbaum, MD, Professor Emeritus, Molecular Medicine, The Scripps Research Institute, and Chief Medical Officer (consulting), Protego Biopharma, explores the mechanisms of organ damage in TTR amyloidosis (ATTR). This important information focuses on the biophysical and biochemical underpinnings of misfolded transthyretin (TTR) leading to tissue dysfunction in this disease.

Transthyretin (TTR) Amyloidosis: Current Diagnostic Approaches in the Clinic
Justin L. Grodin, MD, MPH, Assistant Professor of Medicine, UT Southwestern Medical Center (Dallas, TX), presents a diagnostic algorithmic approach for the establishment of a firm diagnosis of ATTR, with a focus on ATTR patients with heart manifestations (cardiomyopathy).

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